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Relationship of gastric lymphoma to Helicobacter pylori infection

Background: gastric lymphoma is concerned with infection of HP. It is important to study relationship and histopathological types for treatment and prognosis. Purposes: to classify the gastric lymphoma by using the new WHO 2001 classification and to evaluate relationship of gastric lymphoma to HP infection. Study design: A total 100 patients with gastric lymphoma at the K hospital. Paraffin- embeded formalin fixed tissues were Hematoxylin-Eosin and immunohistochemical stained to classify and look for Helicobacter pylori. Results: Of the 100 tissue samples, 97% were B cell NHK: diffuse, large B cell type is the most common (58,8%), MALToma is second (24,7%) with 16/24 high grade cases and 8/24 low grade cases, small cell type is 9,3%. T cell NHK are rare (3%), all are enteropathy-associated T-cell type. 30% of patients is infected by HP. In B cell NHK, ratio of HP infection: MALToma (66,7%) with low grade MALToma (75%) and high grade MALToma (62,5%), lymphoblastic lymphoma (66,7%), diffuse, large B cell lymphoma (15,5%). T cell NHK with HP positive is 66,7%. Conclusions: Low grade MALToma is concerned significantly with infection of HP and immunohistochemical stain is important to identify exactly B cell and T cell phenotype.
Histopathological and immunohistochemical study in the classification of lymph node lesions
One thousand eight hundred and fifty eight lymph node biopsies carried out at K Hospital were histologically and immunohistochemically analyzed. Results indicated that most common lesions were lymph node metastasis (35.25%), chronic lymphadenitis (20.82%), tuberculous lymphadenitis (19.42%) and non Hodgkin lymphoma (18.62%). Histological typing of metastasis revealed that the most frequent types were undifferentiated carcinomas (28,13%), squamous carcinomas (23,7%), adenocarcinomas (16,97%) and type-unspecified carcinoma (13,3%). Non Hodgkin lymphoma rate was higher than that of Hodgkin lymphoma (86,06% versus 12.8%). Immunopheotyping of non Hodgkin lymphomas showed that 79.71% were B cell type, 18.15% were T cell type and 2.14% were Ki-1 type. The most common types of B cell lymphomas were diffuse large B cell lymphomas (35.57%), follicular lymphomas (25.9%) and diffuse small B cell lymphomas (13.83%). The most common types of T cell lymphomas were lymphoblastic T cell lymphomas (41.8%), large T cell lymphomas (23.53%) and unspecified periphery T cell lymphomas.(11.76%). Immunohistochemical analysis of metastasis allowed to identify immunophenotypes of different types of metastatic carcinoma and melanoma and estimate the origin of unknown primary metastasis.
Classifying the gastrointestinal non-Hodgkin’s lymphoma (NHL) by using the new WHO 2001 classification
Background:
The gastrointestinal non-Hodgkin’s lymphoma (NHL) is the most common extranodal site of presentation. Purpose: To classify the gastrointestinal non-Hodgkin’s lymphoma (NHL) by using the new WHO 2001 classification. Study design: A total 62 patients with gastrointestinal NHL at the K hospital. Paraffin - embeded formalin fixed tissuses were immunohistochemical stained to classify. Results: Of the 62 tissuse samples, 96,8% were B cell NHK: diffuse, large B cell type is the most common (71,7%), MALToma is second (13,3%), small cell type is 6,7% and another types is rare. T cell NHK are rare (3,2%), all are lymphoblastic type. The stomach is major organ involved by gastrointestinal lymphoma (59,7%), colorectum is 33,9%, small intestinal NHL is rare (6,5%). Conclusions: Our results indicate that the stomach is a major organ involved by gastrointestinal lymphoma and diffuse, large B cell type is the most common in the gastrointestinal NHL. Immunohistochemical stain plays an important role to classify NHL.
Immunohistochemical study on p53 mutations in breast cancer
Background:
Mutations of the p53 gene appear to be one of the most common abnormalities in human cancer. Nearly one-third of breast cancer have mutations in the p53 gene, which are associated with high histological grade and clinical aggressiveness. Immunohistochemical assays generally detect nuclear accumulational alterations and a prolonged hafl-life of the encoded protein. The purpose of this study was to determine the expression of mutant p53 in breast cancer. Study design: A total 170 patient with breast carcinoma at the K hospital. Paraffin - embeded formalin fixed tissuses, using tissuse array method, were immunohistochemical stained with p53 monoclonal antibody. Results: Of the 170 carcinoma tissuse sample, 34,7% were positive for p53 protein accumulation. P53 positive tumors had decreased from level (+) to level (+++). P53 protein accumulation had increased with high histological grade (grade I: 28,6%, grade II: 36,0% and grade III: 70,0%) (p=0,14) and lymph node positive status (1-3 lymph nodes: 27,8%, 4-9 lymph nodes: 41,7%, and 10 lymph nodes: 83,3%) (p=0,25). Conclusions: Our results indicate that p53 expression is associated with high histological grade and lymph node positive breast carcinoma.
Histologic study and some immunohistochemical features of gastric cancer in Ha Noi K hospital from 1/2002 to 6/2003.
  A histologic study on gastric cancers was carried out on 198 diagnosed gastric cancer at the Pathological Department of K Hospital. The purposes of the study are to determine the features of histologic types of gastric cancer and the contribution of the immunohistochemitry in the diagnosis of gastric cancers. All the cases were stained for hematoxilin and eosin, some cases with mucinous secretion were stained for PAS. Immunohistochemically,  staining 32 cases for P53, 29 gastric adenocarcinoma: diffuse and intestinal types were stained for CK7 and CK20, the non-epthelial gastric cancer were stained for vimentin, CD117, CD34, CK and desmin;  some case of suspected neuroendocrine tumors were stained for chromogranin, CK, MSA, and CD34. Results: (1) The great majority of gastric cancer are gastric carcinomas (93,4%), the non-epthelial gastric cancer are rare (5,6%): stromal tumors (3,6%), malignant lymphomas (2,0%). Gastric neuroendocrine tumor and malignant melanoma are very rare (0,5%). (2) Immunohistotry is very useful in the diagnosis of the non-epthelial gastric cancer. P53 maker is hepful to identify premalignant and malignant lessions. CK7 is positive with most diffuse type, in contrast, CK20 is positive with most intestinal type. The significance of the data was discused.
Studying Ki-67, p53, CK7 vµ CK20 expression and clinical staging of gastric cancer in Ha Noi K hospital
  Background:
Gastric cancer is one of the most common cancer in the world. Immunohistochemistry plays an important role for diagnosis and prognosis. Purposes of the study are to determine the expression of CK7, CK20, Ki-67 and p53 markers and relationship to clinical stage. Objects and method: A Immunohistochemical study on gastric cancers was carried out on 78 diagnosed gastric cancer at the Pathological Department of K Hospital. Results: expression of Ki-67, p53, CK7 and CK20 markers are positive (67,9%, 44,9%, 42,3% and 28,2% in turn). Coexpresion of positive Ki-67 and p53 are the most common (76,9%) (p<0,001). In contrary, coexpression of negative CK7 and CK20 are the most common (37,2%) (p>0,05). Positive Ki-67 and p53 are the most common in stage IV (80% and 70% in turn). Conclusions:  expression of Ki-67 and p53 are combined significally in gastric cancer. Expression of Ki-67 and p53 tend to increase with clinical stage.


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U NGUYÊN BÀO THẦN KINH Ở TRẺ EM 12/4/2007 2:52:14 PM
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<p><strong>Chuyen cua chau Nguyen Ngoc Khanh</strong></p>
<p>Anh <strong>Đặng Đ&igrave;nh Thiết</strong><br/>(ảnh chụp năm 2006)</p>
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